The game begins with Spider Man searching for Mary Jane Watson while the city of New York is infested with symbiotes He finds her with Luke Cage but then sees a mysterious figure and is attacked During a flashback to four days earlier Spider Man retells his account of how his encounter with Venom ended with a piece of the symbiote binding to himself After the fight with Venom a hurt Mary Jane is sent to a hospital and meets Luke Cage during a gang war Cage explains that the Rolling Sevens and Park Avenue gangs are at war and that their task is to bring the two to a truce After pursuing the two gang leaders across the city Spider Man manages to get them to agree to a peaceful meeting in Central Park